compiled by doctordee
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Vinorelbine, or navelbine, is a vinca alkaloid drug that has been used to treat advanced sarcomas, in heavily pretreated patients.
With LMS, navelbine seems to be used following upon a gemcitabine response that has progressed to resistance. There have been three patients on the ACOR LMS List who have been placed on navelbine.
Case 1 was a middle-aged male who had a partial response to Gemcitabine, but tumors grew after 3 months. Navelbine was tried, but progression continued.
Case 2 is an older woman with low grade stage IV Uterine LMS. She was unable to tolerate Gemcitabine because of gemcitabine-induced-hepatitis [two challenges]. She was placed on Navelbine, and had stable disease for 10 to 11 months.
Case 3 is an elderly lady with stage IV extremity LMS. She had a 10 or 11 month period of stable disease with Gemcitabine, then another 3 to 6 months of stable disease off chemotherapy. She had a bad pulmonary reaction to the Navelbine, and stopped it.
"Vinorelbine also induced responses in patients who had become resistant to regimens that included other vinca alkaloids. Overall, Vinorelbine was well tolerated. Toxicity, including neurologic toxicity, was mild and reversible. Neutropenia was the most frequent dose-limiting toxicity."
Fetch PMID: 10735904
Myelosuppression of all elements of the blood occurs. Grade 3 to 4 Neutropenia in 63%, Grade 3 anemia in 9%, and Grade 3 thrombocytopenia in 3%. Nonhematological toxicity [constipation and neurologic toxicity have been mentioned] was generally mild [less than Grade 3] and reversible.
Fetch PMID: 12115359
Further Information: Fetch PMID: 9157072
|URLs for Patient Information|
Online Patient Information
MedlinePlus Drug Information
CancerBacup Drug Information
CancerSource Drug Information
Medscape Drug Information. Registration is free.
|Clinical Trial Results|
The Clinical Trials results are the experiments done in the past to see if the drug works, and how well, and for how long.
Directions for use:
When you click on the search link, it will connect you to Pubmed and display the first 20 citations [which they will call Summaries]. What you WANT is the complete listing of all the summaries of the article [which they will call Abstracts. ]
Go to the second toolbar, and use the drop down menu to change summaries to Abstracts, and 20 to 200, and sort by DATE, and then click on DISPLAY on that same toolbar. You may have to wait while the page loads.
NOW you can save this search to a folder on your hard drive as "Navelbine Clinical Trials" as an HTML file - or as a text file. The entire file, or just those parts which you wish to discuss, can be printed out and taken to talk over with your doctor.
Search Pubmed for ALL articles on vinorelbine
Search Pubmed for Vinorelbine clinical trials and sarcoma
Search Pubmed for Vinorelbine and sarcoma
Search Pubmed for Vinorelbine + Gemcitabine
You will have to go to the site and search.
ASCO abstracts search page
compiled by doctordee
updated October 2003
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