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Navelbine [Vinorelbine]
compiled by doctordee
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General Considerations

Vinorelbine, or navelbine, is a vinca alkaloid drug that has been used to treat advanced sarcomas, in heavily pretreated patients.

With LMS, navelbine seems to be used following upon a gemcitabine response that has progressed to resistance. There have been three patients on the ACOR LMS List who have been placed on navelbine.

Case 1 was a middle-aged male who had a partial response to Gemcitabine, but tumors grew after 3 months. Navelbine was tried, but progression continued.

Case 2 is an older woman with low grade stage IV Uterine LMS. She was unable to tolerate Gemcitabine because of gemcitabine-induced-hepatitis [two challenges]. She was placed on Navelbine, and had stable disease for 10 to 11 months.

Case 3 is an elderly lady with stage IV extremity LMS. She had a 10 or 11 month period of stable disease with Gemcitabine, then another 3 to 6 months of stable disease off chemotherapy. She had a bad pulmonary reaction to the Navelbine, and stopped it.

"Vinorelbine also induced responses in patients who had become resistant to regimens that included other vinca alkaloids. Overall, Vinorelbine was well tolerated. Toxicity, including neurologic toxicity, was mild and reversible. Neutropenia was the most frequent dose-limiting toxicity."
Fetch PMID: 10735904

Myelosuppression of all elements of the blood occurs. Grade 3 to 4 Neutropenia in 63%, Grade 3 anemia in 9%, and Grade 3 thrombocytopenia in 3%. Nonhematological toxicity [constipation and neurologic toxicity have been mentioned] was generally mild [less than Grade 3] and reversible.
Fetch PMID: 12115359

Further Information: Fetch PMID: 9157072
URLs for Patient Information

Navelbine [Vinorelbine]
Online Patient Information

MedlinePlus Drug Information

CancerBacup Drug Information

CancerSource Drug Information

Medscape Drug Information. Registration is free.
Clinical Trial Results
The Clinical Trials results are the experiments done in the past to see if the drug works, and how well, and for how long.

PubMed Searches
Directions for use:

When you click on the search link, it will connect you to Pubmed and display the first 20 citations [which they will call Summaries]. What you WANT is the complete listing of all the summaries of the article [which they will call Abstracts. ]

Go to the second toolbar, and use the drop down menu to change summaries to Abstracts, and 20 to 200, and sort by DATE, and then click on DISPLAY on that same toolbar. You may have to wait while the page loads.

NOW you can save this search to a folder on your hard drive as "Navelbine Clinical Trials" as an HTML file - or as a text file. The entire file, or just those parts which you wish to discuss, can be printed out and taken to talk over with your doctor.

Search Pubmed for ALL articles on vinorelbine

Search Pubmed for Vinorelbine clinical trials and sarcoma

Search Pubmed for Vinorelbine and sarcoma

Search Pubmed for Vinorelbine + Gemcitabine

ASCO Searches

You will have to go to the site and search.

ASCO abstracts search page

compiled by doctordee
updated October 2003

The information on this site is not a substitute for professional medical advice. You should not use this information to diagnose or treat a health problem or disease without consulting with your doctor. Please consult your doctor with any questions or concerns you may have regarding your condition. Copyright 2001-2010 LMSWEBSITE