Research Articles

Soft Tissue Sarcoma

New:

  • In select sarcoma subtypes, researchers determined the disease control rate (DCR) with sorafenib plus dacarbazine. They examined patients with leiomyosarcoma (LMS), synovial sarcoma (SS), or malignant peripheral nerve sheath tumors (MPNST) with up to two previous lines of therapy and adequate hepatic, renal, and marrow function. Treatment regimen for these subjects comprised 3-week cycles of sorafenib at 400 mg oral twice daily and dacarbazine 1,000 mg/m2 intravenously (later reduced to 850 mg/m2). An 18-week DCR of 46% was documented in this study. Modest clinical activity of dacarbazine + sorafenib was evident in patients with these diagnoses. Dacarbazine + sorafenib was feasible and related to favorable disease-control rates; however, this combination also increased the potential for significant toxicity. Read the full article on The Oncologist
NTRK fusion is associated with several cancers, including infantile fibrosarcoma, which can require amputation or morbid surgery when disease is locally advanced. For this phase 1/2 trial (ClinicalTrials.gov Identifier: NCT02637687), researchers enrolled 11 patients with infantile fibrosarcoma (7 patients) or another sarcoma subtype (4 patients) to receive larotrectinib followed by surgery.
“This is very exciting, but only applies to 0.1% of sarcomas.  But, it is worth looking into more.  I have seen one sarcoma with
one NTRK fusion and it was very exciting.” – from Dr. Neeta Somaiah, MD, Sarcoma Research, Anderson Cancer Center.

A phase II study of tumor ablation in patients with metastatic sarcoma stable on chemotherapy

A retrospective cohort study of treatment patterns among patients with metastatic soft tissue sarcoma in the US

A prediction model for treatment decisions in high-grade extremity soft-tissue sarcomas: Personalised sarcoma care (PERSARC).

A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers

Adjuvant Therapy Does Not Improve Survival for Early Stage Uterine Leiomyosarcoma

Cancer ‘vaccine’ eliminates tumors in mice

Effect of neoadjuvant chemotherapy plus regional hyperthermia on long-term outcomes among patients with localized high-risk soft tissue sarcoma: The EORTC 62961-ESHO 95 randomized clinical trial

Expression and role of TYRO3 and AXL as potential therapeutical targets in leiomyosarcoma

Mocetinostat combined with gemcitabine for the treatment of leiomyosarcoma: Preclinical correlates

Soft Tissue and Uterine Leiomyosarcoma