The NLMSF, SPAEN, and the LMS Community of patients and their families are most grateful for the membership of the International LMS Research Roundtable, coming together to make the difference for the future of survivorship.
The International LMS Research Roundtable Mission: LMS-specific Research and Treatment focus –
“Where Purpose Meets Progress”
THE LEIOMYOSARCOMA GLOBAL SCIENTIFIC THINK TANK
Mission and Of The International LMS Research Roundtable
MAY 7, 2021 RESEARCH GRANT PROPOSAL
CALL FOR RESEARCH PROJECT SUBMISSIONS – See Details: Link
R E S E A R C H R E Q U E S T FOR P R O P O S A L
A global initiative bringing together the Sarcoma Research Community for a collaborative focus on the future of Leiomyosarcoma investigational research/clinical trials with a mission of:
-
- Bringing together the sarcoma experts to have a focused meeting only on Leiomyosarcoma
- Discussing/Understanding the present state of LMS and the continued challenges of research/diagnosis/treatment
- Developing work plans to close the gaps/to improve precision LMS research and LMA patient-treatment protocol – SEE PUBLICATION: https://www.ncbi.
nlm.nih.gov/pmc/articles/ PMC7924026/ - Advising and directing the NLMSF on LMS precision research projects for solicitation and funding for 2020 and beyond
The INTERNATIONAL LMS RESEARCH ROUNDTABLE is comprised of an NLMSF Executive Committee and 100+ Members of the Roundtable in support of this initiative, conceived in 2018 and launched in 2019.
- LMS CELL LINES / PDX MODELS
- PROTEOMICS /MULTIOMICS
- GYNECOLOGIC (STUMP)
- CLINICAL TRIALS ASSESSMENT
Four focus Workgroups currently in progress. Interested Roundtable members are encouraged and welcome to participate in any of the following workgroups to support the goals of each:
- Uterine LMS – Observational protocol for uLMS (Stump) to analyze relapse and non-relapse; evaluate data elements from sarcoma center data submission. Workgroup Leader: Dr. Roberta Sanfilippo; roberta.sanfilippo@gmail.com
- Multi-Omics – Understanding the molecular basis of LMS to inform precision research and ultimately direct LMS specific trials. Also, group aims to addressing issues such as tumor heterogeneity and the development of metastasis, and response to treatment in the neo/adjuvant setting. Workgroup Leader: Dr. Paul Huang; Paul.Huang@icr.ac.uk
- LMS Cell Line / PDX Models– Cultivating tumor samples and bringing forward the LMS tumor cell lines for research purposes. Collecting cell line data for sequencing of cell lines for collaborative analysis. Cell line and PDX data sharing for genomic analysis – now working with the Broad Institute. Workgroup leader: Dr. Matt Hemming; mhemming@partners.org
- Clinical Trials – Tracking LMS trials to analyze outcomes and trends for ongoing and future trial design considerations. Workgroup Leader Dr. Bernd Kasper; Bernd.Kasper@medma.uni-heidelberg.de
PLEASE NOTE:
- If there are new LMS research projects in the pipeline currently or planned for the future, please contact Dr. Kasper, as his workgroup is tracking all clinical trials for further Roundtable discussions: bernd.kasper@medma.uni-heidelberg.de
- For newly published LMS specific articles or research updates that include LMS, please send a the title of the publication and link to: annieachee@aol.com for the Leiomyosarcoma.info research article archives, for up to date information by year.
RESEARCH REQUEST FOR PROPOSAL – APRIL 24, 2020
R E S E A R C H R E Q U E S T FOR P R O P O S A L
The International LMS Research Roundtable initiative, founded in 2018 by the National Leiomyosarcoma Foundation (NLMSF) with the collaborative support of the Sarcoma Patients EuroNet (SPAEN), was set up to proactively accelerate LMS-specific knowledge sharing, research and clinical trial designs to address the specific challenges of LMS. The workgroups emerging from within the Roundtable will be most valuable for contributing to this effort in advancing treatment options for the future.
The National Leiomyosarcoma Foundation’s Roundtable Executive Committee is pleased to announce Request For Proposals (RFP’s) for an award of $50,000 per year x 2 years for submission no later than August 3, 2020. The standardized protocol for this project can be found here: Click here to access RFP Criteria
The selected research project will be announced at the 2020 CTOS meeting with full funding of the project by the NLMSF.
Thank you for your response to the RFP request.
Scott Okuno, MD, Executive Committee Chair
Seth Pollack, MD, RFP Administrator, Exec. Committee
Annie Achee, President, NLMSF
Click here for: LMS Cell & PDX Workgroup Request
Researchers Call to Action- Request for Data:
LMS INTERNATIONAL RESEARCH ROUNDTABLE WORKGROUP No. 1: PDX/CELL LINE Models for LMS